Across TCGA patient cohorts, PRRT1 mutation is significantly associated with the RNA expression of many other genes, with 826 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT1-associated genes across cancer lineages are RPL7AP23, SNORD113-4, and VENTXP7. Each is linked with PRRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRT1-to-partner and partner-to-PRRT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT1→partner) and Y-score (partner→PRRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL7AP23 →	+0.060	+3.408	<.001	.009	3	2
COAD	SNORD113-4 →	+0.610	+2.956	<.001	.004	3	2
COAD	VENTXP7 →	+0.109	+3.698	<.001	<.001	3	2
UCEC	RN7SL219P →	+0.249	+1.791	.003	.003	3	2
SKCM	RANP9 →	+0.301	+4.623	<.001	<.001	3	2
SKCM	OR11K2P →	+0.040	+3.623	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

Exploration

PRRT1 survival (RNA) · tumor vs normal (RNA) · all PRRT1 data types