Across TCGA patient cohorts, PRRT1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRT1-associated genes across cancer lineages are ATM, GAPDH, and MSH2. Each is linked with PRRT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRT1-to-partner and partner-to-PRRT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT1→partner) and Y-score (partner→PRRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.378	-2.986	.038	.035	3	3
UCEC	GAPDH →	+0.522	+3.459	.015	.005	3	2
UCEC	MSH2 →	-0.362	-3.143	<.001	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.796	+2.341	<.001	.019	3	2
UCEC	Cyclin-B1 →	+0.523	+2.321	.020	.034	3	2
UCEC	EGFR_pY1068 →	-0.285	-3.321	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

PRRT1 survival (RNA) · tumor vs normal (RNA) · all PRRT1 data types