PRRG4

Across TCGA pan-cancer cohorts, PRRG4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRRG4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRRG4 RNA is repressed in tumor relative to normal tissue. In most cancer types PRRG4 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

KICH, BRCA, and HNSC are the cancer types where PRRG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRRG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−1.378	<.001	7	view →
BRCA	All	II,III,IV	+0.932	<.001	6	view →
HNSC	All	All	+0.620	.007	5	view →
LUSC	All	All	+0.856	<.001	4	view →
READ	All	All	−0.969	<.001	3	view →
STAD	All	III,IV	+1.123	.030	2	view →
UCEC	All	All	+1.077	.014	2	view →
PRAD	All	All	−0.770	<.001	2	view →
LIHC	All	II,III,IV	−0.636	.020	2	view →
KIRP	All	All	−0.560	.006	2	view →
COAD	All	All	−0.384	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRRG4–KICH

Open the KICH breakdown →