PRRG2

Across TCGA cell cohorts, PRRG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,966 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRRG2-associated GO terms across cancer lineages are Response to indole-3-methanol, Cellular response to indole-3-methanol, and Negative regulation of actin filament bundle assembly. Each is linked with PRRG2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PRRG2-to-partner and partner-to-PRRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by PRRG2-low versus PRRG2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRG2→partner) and Y-score (partner→PRRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to indole-3-methanol →	+0.191	+1.793	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.226	+2.172	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of actin filament bundle assembly →	+0.111	+1.184	.001	.001	3	11
STOMACH	Cytotoxic T cell degranulation →	+0.322	+2.176	<.001	<.001	3	11
URINARY_TRACT	Regulation of ventricular cardiac muscle cell action potential →	+0.205	+2.594	<.001	<.001	3	11
STOMACH	Small GTPase-mediated signal transduction →	+0.057	+2.137	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,966 associations by consensus.

Response to indole-3-methanol by PRRG2 expression — URINARY_TRACT

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