PRRG1

Across TCGA cell cohorts, PRRG1 mutation is significantly associated with the drug of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRG1-associated genes across cancer lineages are Cytarabine, GSK2276186C, and GSK2110183B. Each is linked with PRRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRG1-to-partner and partner-to-PRRG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytarabine grouped by PRRG1-low versus PRRG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRG1→partner) and Y-score (partner→PRRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+0.767	+2.655	.049	.044	3	1
LARGE_INTESTINE	GSK2276186C →	+0.556	+2.649	.015	.046	3	1
LARGE_INTESTINE	GSK2110183B →	+0.676	+2.649	.026	.046	3	1
LARGE_INTESTINE	Dactinomycin →	+0.579	+2.649	.012	.046	3	1
LARGE_INTESTINE	50869 →	+0.479	+2.649	.023	.046	3	1
LARGE_INTESTINE	630600 →	+0.682	+2.649	.028	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Cytarabine by PRRG1 expression — LARGE_INTESTINE

Explore this box plot interactively →