PRRC2C

Across TCGA patient cohorts, PRRC2C mutation is significantly associated with the RNA expression of many other genes, with 4,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRC2C-associated genes across cancer lineages are AUNIP, GPR3, and ZNF280B. Each is linked with PRRC2C in more than 3 cancer types. Because this analysis shows association rather than direction, both PRRC2C-to-partner and partner-to-PRRC2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AUNIP grouped by PRRC2C-low versus PRRC2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2C→partner) and Y-score (partner→PRRC2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AUNIP →	+0.429	+1.958	.002	.002	3	4
COAD	GPR3 →	+0.570	+4.020	<.001	<.001	3	4
UCEC	ZNF280B →	+0.494	+1.595	<.001	<.001	3	4
LUAD	SEH1L →	+0.417	+3.620	.009	.001	3	3
UCEC	SLC25A17 →	+0.284	+1.719	<.001	<.001	3	3
UCEC	PAPLN →	-0.698	-2.222	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,704 associations by consensus.

AUNIP by PRRC2C expression — UCEC

Explore this box plot interactively →