PRRC2C

Across TCGA cell cohorts, PRRC2C mutation is significantly associated with the RNA expression of many other genes, with 2,000 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC2C-associated genes across cancer lineages are SPEM1, CST4, and FZD3. Each is linked with PRRC2C in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRC2C-to-partner and partner-to-PRRC2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEM1 grouped by PRRC2C-low versus PRRC2C-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2C→partner) and Y-score (partner→PRRC2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPEM1 →	+0.043	+2.878	.005	.009	3	3
BLOOD_Lymphoma	CST4 →	+0.347	+3.058	.003	.006	3	3
LARGE_INTESTINE	FZD3 →	+0.625	+2.182	.001	.001	3	3
LARGE_INTESTINE	CSPG5 →	+0.571	+2.459	.002	.003	3	3
LARGE_INTESTINE	SLC22A23 →	+0.646	+2.000	.008	.004	3	3
LARGE_INTESTINE	SETD7 →	+0.708	+3.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,000 associations by consensus.

SPEM1 by PRRC2C expression — SKIN

Explore this box plot interactively →