PRRC2C

Across TCGA cell cohorts, PRRC2C mutation is significantly associated with the mutation status of many other genes, with 4,746 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC2C-associated genes across cancer lineages are PML, EP400, and JARID2. Each is linked with PRRC2C in more than 6 cancer types. Because this analysis shows association rather than direction, both PRRC2C-to-partner and partner-to-PRRC2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML grouped by PRRC2C-low versus PRRC2C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2C→partner) and Y-score (partner→PRRC2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PML →	+3.408	+1.828	<.001	<.001	1	7
UPPER_AERODIGESTIVE_TRACT	EP400 →	+2.321	+3.169	.008	.008	1	7
OVARY	JARID2 →	+2.688	+2.832	.002	.002	1	7
PANCREAS	MYO15A →	+4.777	+3.736	<.001	<.001	1	6
PANCREAS	FBN2 →	+3.777	+3.444	.001	.001	1	6
LARGE_INTESTINE	RBM12B →	+2.993	+1.553	.001	.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,746 associations by consensus.

PML by PRRC2C expression — LARGE_INTESTINE

Explore this box plot interactively →