Across TCGA patient cohorts, PRRC2A mutation is significantly associated with the RNA expression of many other genes, with 5,733 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRRC2A-associated genes across cancer lineages are PPID, TSPY26P, and CHCHD4. Each is linked with PRRC2A in more than 3 cancer types. Because this analysis shows association rather than direction, both PRRC2A-to-partner and partner-to-PRRC2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2A→partner) and Y-score (partner→PRRC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPID →	+0.622	+2.129	<.001	<.001	3	4
SKCM	TSPY26P →	-0.658	-1.302	.001	.005	3	4
CESC	CHCHD4 →	+0.557	+3.184	.001	.009	3	3
UCEC	UHRF1 →	+0.761	+2.140	<.001	<.001	3	3
UCEC	RNA5SP411 →	+0.669	+1.493	<.001	.001	3	3
LIHC	RPL32P6 →	+0.169	+4.378	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,733 associations by consensus.

Exploration

PRRC2A survival (RNA) · tumor vs normal (RNA) · all PRRC2A data types