Across TCGA cell cohorts, PRRC2A mutation is significantly associated with the RNA expression of many other genes, with 2,291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC2A-associated genes across cancer lineages are ACER1, LECT2, and UBE2D3. Each is linked with PRRC2A in more than 2 cancer types. Because this analysis shows association rather than direction, both PRRC2A-to-partner and partner-to-PRRC2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2A→partner) and Y-score (partner→PRRC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.055	+1.823	.003	.003	3	3
UPPER_AERODIGESTIVE_TRACT	LECT2 →	+0.046	+4.209	<.001	.006	3	3
LARGE_INTESTINE	UBE2D3 →	+0.508	+2.949	<.001	<.001	3	3
BLOOD_Leukemia	GATAD2B →	+0.610	+3.199	.004	.007	3	3
LARGE_INTESTINE	FBXW10 →	+0.171	+2.438	.001	<.001	3	3
LARGE_INTESTINE	ATP2A1 →	+0.724	+2.265	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,291 associations by consensus.

Exploration

PRRC2A survival (RNA) · tumor vs normal (RNA) · all PRRC2A data types