Across TCGA cell cohorts, PRRC2A mutation is significantly associated with the mutation status of many other genes, with 6,744 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC2A-associated genes across cancer lineages are ATP2B2, PRRC2B, and PARD3. Each is linked with PRRC2A in more than 6 cancer types. Because this analysis shows association rather than direction, both PRRC2A-to-partner and partner-to-PRRC2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC2A→partner) and Y-score (partner→PRRC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP2B2 →	+4.142	+2.857	.008	.008	1	7
BLOOD_Lymphoma	PRRC2B →	+3.938	+3.731	<.001	<.001	1	7
BLOOD_Lymphoma	PARD3 →	+3.938	+3.731	<.001	<.001	1	7
UPPER_AERODIGESTIVE_TRACT	NIN →	+4.954	+4.392	.008	.008	1	6
STOMACH	PCDHA13 →	+4.584	+3.942	.002	.002	1	6
BLOOD_Leukemia	CDH18 →	+3.584	+2.845	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,744 associations by consensus.

Exploration

PRRC2A survival (RNA) · tumor vs normal (RNA) · all PRRC2A data types