PRRC1

Across TCGA cell cohorts, PRRC1 mutation is significantly associated with the mutation status of many other genes, with 3,380 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC1-associated genes across cancer lineages are LIMK2, SMARCA2, and DOP1A. Each is linked with PRRC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRRC1-to-partner and partner-to-PRRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIMK2 grouped by PRRC1-low versus PRRC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC1→partner) and Y-score (partner→PRRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LIMK2 →	+5.169	+5.832	<.001	<.001	1	4
LARGE_INTESTINE	SMARCA2 →	+2.347	+4.392	<.001	<.001	1	3
LARGE_INTESTINE	DOP1A →	+2.263	+3.392	.001	.001	1	3
BREAST	TAOK3 →	+5.297	+5.297	.004	.004	1	3
BREAST	ADGRG7 →	+4.297	+4.857	.009	.009	1	3
BREAST	DDX21 →	+4.297	+4.857	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,380 associations by consensus.

LIMK2 by PRRC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →