PRRC1

Across TCGA cell cohorts, PRRC1 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRRC1-associated genes across cancer lineages are AZD7762, MK-1775, and Phenformin. Each is linked with PRRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRC1-to-partner and partner-to-PRRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD7762 grouped by PRRC1-low versus PRRC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRC1→partner) and Y-score (partner→PRRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD7762 →	+0.555	+2.646	.029	.047	3	1
LARGE_INTESTINE	MK-1775 →	+0.337	+2.646	.038	.047	3	1
LARGE_INTESTINE	Phenformin →	+0.872	+2.652	.009	.045	3	1
LARGE_INTESTINE	TAK-715 →	+0.510	+2.786	.013	.037	3	1
LARGE_INTESTINE	CX-5461 →	+0.656	+2.652	.026	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.586	+2.652	.021	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AZD7762 by PRRC1 expression — LARGE_INTESTINE

Explore this box plot interactively →