Across TCGA cell cohorts, PRR5 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRR5-associated genes across cancer lineages are MAGEB5, RAMP3, and TMCO5A. Each is linked with PRR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR5-to-partner and partner-to-PRR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR5→partner) and Y-score (partner→PRR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	RAMP3 →	+0.258	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TMCO5A →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPR171 →	+0.019	+4.273	<.001	.006	3	1
LARGE_INTESTINE	KCTD8 →	+0.183	+4.095	.003	.009	3	1
LARGE_INTESTINE	FAM162B →	+0.158	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

PRR5 survival (RNA) · tumor vs normal (RNA) · all PRR5 data types