PRR33

Across TCGA cell cohorts, PRR33 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,916 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRR33-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Regulation of telomere maintenance, and Integrin-mediated signaling pathway. Each is linked with PRR33 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRR33-to-partner and partner-to-PRR33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by PRR33-low versus PRR33-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR33→partner) and Y-score (partner→PRR33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of alternative mRNA splicing, via spliceosome →	+0.088	+0.340	<.001	.001	3	7
SOFT_TISSUE	Regulation of telomere maintenance →	+0.053	+0.310	<.001	.002	3	6
LUNG_NSCLC_LUAD	Integrin-mediated signaling pathway →	+0.101	+0.037	.002	.009	3	6
UPPER_AERODIGESTIVE_TRACT	Amacrine cell differentiation →	-0.123	-0.261	.006	.008	3	6
SOFT_TISSUE	Negative regulation of translational initiation →	+0.077	+0.332	<.001	.001	3	6
SOFT_TISSUE	Regulation of telomere maintenance via telomere lengthening →	+0.030	+0.177	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,916 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by PRR33 expression — SOFT_TISSUE

Explore this box plot interactively →