Across TCGA patient cohorts, PRR30 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR30-associated genes across cancer lineages are Notch1, PCNA, and Caspase-8. Each is linked with PRR30 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR30-to-partner and partner-to-PRR30 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR30→partner) and Y-score (partner→PRR30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.174	+3.013	.002	.018	3	2
UCEC	PCNA →	+0.254	+3.321	.004	.009	3	2
UCEC	Caspase-8 →	-0.247	-1.973	.017	.029	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.321	.025	.006	3	1
UCEC	MEK1 →	+0.402	+2.459	.007	.019	3	1
UCEC	p62 Lck ligand →	+0.389	+1.807	.003	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PRR30 survival (RNA) · tumor vs normal (RNA) · all PRR30 data types