Across TCGA pan-cancer cohorts, PRR3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PRR3 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRR3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PRR3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where PRR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.990	0.650	.013	16	view →
LUAD	DFS	Median	All	0.971	0.816	.015	7	view →
UCEC	OS	Quartile	All	0.873	1.000	.018	6	view →
GBM	OS	Tertile	All	0.463	0.277	.025	5	view →
LSCC	OS	Median	All	0.733	1.000	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PRR3 tumor-vs-normal RNA expression · all PRR3 data types