Across TCGA patient cohorts, PRR3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR3-associated genes across cancer lineages are CD20, ERK2, and Ku80. Each is linked with PRR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR3-to-partner and partner-to-PRR3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR3→partner) and Y-score (partner→PRR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD20 →	+0.217	+3.020	.004	.019	3	2
UCEC	ERK2 →	+0.330	+3.000	.003	.037	3	1
UCEC	Ku80 →	+0.358	+3.013	.008	.019	3	1
UCEC	PDCD4 →	-1.199	-2.990	<.001	.036	2	2
UCEC	PEA-15_pS116 →	+0.599	+3.000	.003	.037	3	1
UCEC	Rb_pS807_S811 →	-0.556	-3.000	.017	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

PRR3 survival (RNA) · tumor vs normal (RNA) · all PRR3 data types