Across TCGA patient cohorts, PRR22 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR22-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Ku80. Each is linked with PRR22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR22-to-partner and partner-to-PRR22 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR22→partner) and Y-score (partner→PRR22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.292	-3.169	.016	.019	3	1
UCEC	A-Raf_pS299 →	-0.223	-3.169	<.001	.019	3	1
UCEC	Ku80 →	+0.362	+3.009	.001	.019	3	1
UCEC	mTOR_pS2448 →	-0.209	-2.980	.003	.036	3	1
UCEC	Notch1 →	+0.176	+2.459	.009	.020	3	1
UCEC	PCNA →	+0.324	+2.459	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

PRR22 survival (RNA) · tumor vs normal (RNA) · all PRR22 data types