Across TCGA cell cohorts, PRR22 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRR22-associated genes across cancer lineages are ASCL4, DMRTC2, and NCAN. Each is linked with PRR22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR22-to-partner and partner-to-PRR22 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR22→partner) and Y-score (partner→PRR22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ASCL4 →	+0.016	+5.169	<.001	.004	3	1
BLOOD_Leukemia	DMRTC2 →	+0.049	+5.539	<.001	.003	3	1
LARGE_INTESTINE	NCAN →	+0.180	+3.629	<.001	.003	3	1
LARGE_INTESTINE	ST6GAL2 →	+0.921	+3.451	<.001	.005	3	1
LARGE_INTESTINE	ARL13A →	+0.081	+3.369	<.001	.007	3	1
LARGE_INTESTINE	PROP1 →	+0.017	+2.791	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PRR22 survival (RNA) · tumor vs normal (RNA) · all PRR22 data types