Across TCGA patient cohorts, PRR16 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR16-associated genes across cancer lineages are Cyclin-B1, ATM, and 4E-BP1. Each is linked with PRR16 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRR16-to-partner and partner-to-PRR16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR16→partner) and Y-score (partner→PRR16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.411	+2.334	.035	.018	3	2
UCEC	ATM →	-0.432	-2.000	.015	.030	3	2
UCEC	4E-BP1 →	+0.345	+2.489	.001	.010	2	3
SKCM	E-Cadherin →	-1.188	-3.000	.004	.035	2	2
UCEC	eIF4G →	+0.269	+1.584	.027	.036	3	1
UCEC	FoxM1 →	+0.217	+1.584	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PRR16 survival (RNA) · tumor vs normal (RNA) · all PRR16 data types