PRR14

Across TCGA patient cohorts, PRR14 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR14-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with PRR14 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRR14-to-partner and partner-to-PRR14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PRR14-low versus PRR14-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR14→partner) and Y-score (partner→PRR14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.353	+3.008	.005	.019	3	3
COAD	Caspase-7-cleavedD198 →	+1.592	+3.008	<.001	.019	3	3
UCEC	EGFR_pY1068 →	-0.221	-2.000	.025	.030	3	2
UCEC	GAPDH →	+0.692	+2.502	<.001	.002	3	2
UCEC	Shc_pY317 →	-0.152	-2.000	.010	.030	3	2
COAD	Cyclin-E1 →	+0.330	+3.008	.011	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PCNA by PRR14 expression — COAD

Explore this box plot interactively →