PRR14

Across TCGA cell cohorts, PRR14 mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRR14-associated genes across cancer lineages are LRRC3C, TMEM213, and LACTBL1. Each is linked with PRR14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR14-to-partner and partner-to-PRR14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by PRR14-low versus PRR14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR14→partner) and Y-score (partner→PRR14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.224	+3.337	<.001	<.001	3	2
BLOOD_Leukemia	TMEM213 →	+0.108	+4.169	<.001	.003	3	2
LUNG_NSCLC_LUAD	LACTBL1 →	+0.007	+5.189	<.001	<.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.034	+4.060	<.001	.003	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

LRRC3C by PRR14 expression — LARGE_INTESTINE

Explore this box plot interactively →