PRPSAP2

Across TCGA pan-cancer cohorts, PRPSAP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRPSAP2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRPSAP2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRPSAP2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where PRPSAP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.915	1.000	.009	36	view →
CCRCC	DFS	Median	All	0.919	0.554	.011	29	view →
LUAD	DFS	Tertile	All	1.000	0.545	.001	29	view →
HNSC	DFS	Median	III,IV	0.265	0.895	.001	18	view →
OV	DFS	Tertile	All	0.441	0.844	.025	16	view →
PDAC	OS	Tertile	All	0.604	0.320	.008	15	view →
UCEC	OS	Median	All	0.899	1.000	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRPSAP2–COAD (DFS)

Open the COAD breakdown →