PRPS2

Across TCGA patient cohorts, PRPS2 mutation is significantly associated with the RNA expression of many other genes, with 1,628 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPS2-associated genes across cancer lineages are CDH12P1, LINC02349, and MTATP6P21. Each is linked with PRPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPS2-to-partner and partner-to-PRPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH12P1 grouped by PRPS2-low versus PRPS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS2→partner) and Y-score (partner→PRPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDH12P1 →	+0.092	+4.614	<.001	.006	3	2
SKCM	LINC02349 →	+0.082	+4.385	<.001	.008	3	2
UCEC	MTATP6P21 →	+0.216	+1.645	<.001	.008	3	2
UCEC	PRPS1P1 →	+0.068	+1.868	.001	.005	3	2
UCEC	RN7SL354P →	+0.153	+1.526	.002	.007	3	2
UCEC	RNA5SP413 →	+1.040	+1.649	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,628 associations by consensus.

CDH12P1 by PRPS2 expression — SKCM

Explore this box plot interactively →