PRPS2

Across TCGA cell cohorts, PRPS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,962 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPS2-associated GO terms across cancer lineages are 5-phosphoribose 1-diphosphate metabolic process, 5-phosphoribose 1-diphosphate biosynthetic process, and Pentose-phosphate shunt. Each is linked with PRPS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PRPS2-to-partner and partner-to-PRPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 5-phosphoribose 1-diphosphate metabolic process grouped by PRPS2-low versus PRPS2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS2→partner) and Y-score (partner→PRPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	5-phosphoribose 1-diphosphate metabolic process →	+0.195	+1.470	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	5-phosphoribose 1-diphosphate biosynthetic process →	+0.195	+1.470	<.001	<.001	3	17
LUNG_SCLC	Pentose-phosphate shunt →	+0.155	+0.954	<.001	<.001	2	17
BREAST	NADPH regeneration →	+0.111	+1.668	.001	.001	3	16
OVARY	Nucleoside monophosphate biosynthetic process →	+0.119	+1.057	<.001	<.001	3	12
BLOOD_Leukemia	Spindle elongation →	+0.164	+0.850	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,962 associations by consensus.

5-phosphoribose 1-diphosphate metabolic process by PRPS2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →