Across TCGA patient cohorts, PRPS1L1 mutation is significantly associated with the RNA expression of many other genes, with 1,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPS1L1-associated genes across cancer lineages are RNU6-847P, RNU6-603P, and RN7SL111P. Each is linked with PRPS1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPS1L1-to-partner and partner-to-PRPS1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS1L1→partner) and Y-score (partner→PRPS1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-847P →	+0.353	+5.339	<.001	.003	3	3
HNSC	RNU6-603P →	+0.355	+4.505	<.001	.009	3	3
BLCA	RN7SL111P →	+0.258	+4.844	<.001	<.001	3	3
UCEC	RNU6-629P →	+0.201	+3.722	<.001	.001	3	3
HNSC	RNA5SP251 →	+0.201	+4.578	.005	.008	3	2
UCEC	RNF126 →	+0.500	+2.732	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,314 associations by consensus.

Exploration

PRPS1L1 survival (RNA) · tumor vs normal (RNA) · all PRPS1L1 data types