Across TCGA patient cohorts, PRPS1L1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPS1L1-associated genes across cancer lineages are ER-alpha_pS118, MEK1, and MSH2. Each is linked with PRPS1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPS1L1-to-partner and partner-to-PRPS1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS1L1→partner) and Y-score (partner→PRPS1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	-0.343	-3.584	.047	.002	3	1
UCEC	MEK1 →	+0.410	+2.459	.020	.020	3	1
UCEC	MSH2 →	-0.415	-3.295	<.001	.009	3	1
UCEC	Myosin-IIa →	+0.219	+3.592	.014	.001	3	1
UCEC	p62 Lck ligand →	+0.331	+2.817	.035	.036	3	1
UCEC	Beclin →	+0.153	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

PRPS1L1 survival (RNA) · tumor vs normal (RNA) · all PRPS1L1 data types