Across TCGA cell cohorts, PRPS1L1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRPS1L1-associated genes across cancer lineages are OR9A2, C1orf87, and OR1M1. Each is linked with PRPS1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPS1L1-to-partner and partner-to-PRPS1L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS1L1→partner) and Y-score (partner→PRPS1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.018	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	C1orf87 →	+0.056	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR1M1 →	+0.019	+5.209	<.001	.005	3	1
SKIN	MYG1 →	+0.512	+3.067	.002	.009	3	1
SKIN	ANKRD30A →	+0.117	+3.363	<.001	<.001	3	1
SKIN	LRTM2 →	+0.133	+2.556	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

PRPS1L1 survival (RNA) · tumor vs normal (RNA) · all PRPS1L1 data types