PRPS1

Across TCGA pan-cancer cohorts, PRPS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRPS1 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PRPS1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRPS1 expression acts as an unfavorable survival marker.

ACC, SKCM, and READ are the cancer types where PRPS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
SKCM	OS	Median	All	0.202	0.787	<.001	15	view →
READ	OS	Median	II,III,IV	0.187	0.644	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PRPS1–ACC (DFS)

Open the ACC breakdown →