PRPS1

Across TCGA patient cohorts, PRPS1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPS1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ERK2. Each is linked with PRPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPS1-to-partner and partner-to-PRPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PRPS1-low versus PRPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS1→partner) and Y-score (partner→PRPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.113	-2.780	.002	.003	3	1
UCEC	eIF4E →	+0.195	+1.847	.011	.008	3	1
UCEC	ERK2 →	+0.192	+2.247	.006	.001	3	1
UCEC	ACC_pS79 →	+0.374	+2.247	.003	.001	3	1
UCEC	ACC1 →	+0.376	+3.472	.004	.002	3	1
UCEC	Heregulin →	-0.098	-1.584	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by PRPS1 expression — UCEC

Explore this box plot interactively →