PRPS1

Across TCGA cell cohorts, PRPS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPS1-associated GO terms across cancer lineages are DNA replication initiation, Mitotic spindle elongation, and Mitotic spindle midzone assembly. Each is linked with PRPS1 in more than 14 cancer types. Because this analysis shows association rather than direction, both PRPS1-to-partner and partner-to-PRPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PRPS1-low versus PRPS1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS1→partner) and Y-score (partner→PRPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNA replication initiation →	+0.166	+1.270	<.001	<.001	3	15
STOMACH	Mitotic spindle elongation →	+0.261	+1.508	<.001	<.001	3	14
STOMACH	Mitotic spindle midzone assembly →	+0.261	+1.508	<.001	<.001	3	14
STOMACH	Spindle elongation →	+0.250	+1.280	<.001	<.001	3	14
PANCREAS	Nucleoside monophosphate biosynthetic process →	+0.129	+2.141	<.001	<.001	3	14
STOMACH	CENP-A containing chromatin assembly →	+0.161	+1.376	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

DNA replication initiation by PRPS1 expression — STOMACH

Explore this box plot interactively →