PRPH2

Across TCGA patient cohorts, PRPH2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPH2-associated genes across cancer lineages are VHL, ATM, and 14-3-3_beta. Each is linked with PRPH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPH2-to-partner and partner-to-PRPH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PRPH2-low versus PRPH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPH2→partner) and Y-score (partner→PRPH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.079	-2.222	<.001	.011	3	2
UCEC	ATM →	-0.781	-2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.086	-2.973	.043	.035	3	1
UCEC	FoxM1 →	+0.219	+1.700	.046	.044	3	1
UCEC	INPP4B →	-0.339	-3.169	.013	.018	3	1
UCEC	Ku80 →	+0.201	+1.713	.045	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

VHL by PRPH2 expression — UCEC

Explore this box plot interactively →