PRPF8

Across TCGA cell cohorts, PRPF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,114 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPF8-associated GO terms across cancer lineages are DNA-templated transcription initiation, snRNA export from nucleus, and 'de novo' IMP biosynthetic process. Each is linked with PRPF8 in more than 14 cancer types. Because this analysis shows association rather than direction, both PRPF8-to-partner and partner-to-PRPF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by PRPF8-low versus PRPF8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF8→partner) and Y-score (partner→PRPF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.076	+0.811	<.001	<.001	3	15
BONE	snRNA export from nucleus →	+0.149	+0.803	.002	<.001	3	15
LIVER	'de novo' IMP biosynthetic process →	+0.147	+0.906	<.001	<.001	3	15
BONE	IMP biosynthetic process →	+0.174	+0.699	<.001	.003	3	14
BREAST	Regulation of G1 to G0 transition →	+0.164	+0.887	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Protein localization to nucleoplasm →	+0.159	+0.875	<.001	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,114 associations by consensus.

DNA-templated transcription initiation by PRPF8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →