PRPF6

Across TCGA pan-cancer cohorts, PRPF6 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PRPF6 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRPF6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRPF6 expression acts as an unfavorable survival marker.

UCEC and BLCA are the cancer types where PRPF6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	IV	0.146	0.479	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PRPF6–UCEC (OS)

Open the UCEC breakdown →