PRPF6

Across TCGA cell cohorts, PRPF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,460 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF6-associated GO terms across cancer lineages are Regulation of telomeric loop disassembly, Maternal-to-zygotic transition of gene expression, and Negative regulation of t-circle formation. Each is linked with PRPF6 in more than 14 cancer types. Because this analysis shows association rather than direction, both PRPF6-to-partner and partner-to-PRPF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric loop disassembly grouped by PRPF6-low versus PRPF6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF6→partner) and Y-score (partner→PRPF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of telomeric loop disassembly →	+0.146	+0.990	<.001	<.001	3	15
BLOOD_Leukemia	Maternal-to-zygotic transition of gene expression →	+0.184	+0.344	<.001	<.001	3	13
PANCREAS	Negative regulation of t-circle formation →	+0.154	+0.726	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of DNA-templated transcription initiation →	+0.073	+0.777	<.001	<.001	3	12
LARGE_INTESTINE	Regulation of mRNA processing →	+0.089	+0.811	<.001	<.001	3	11
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.120	+0.813	<.001	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

Regulation of telomeric loop disassembly by PRPF6 expression — SOFT_TISSUE

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