PRPF4B

Across TCGA patient cohorts, PRPF4B mutation is significantly associated with the RNA expression of many other genes, with 3,524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF4B-associated genes across cancer lineages are MAGEA9B, HBZP1, and RNA5SP415. Each is linked with PRPF4B in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF4B-to-partner and partner-to-PRPF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEA9B grouped by PRPF4B-low versus PRPF4B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF4B→partner) and Y-score (partner→PRPF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAGEA9B →	+1.131	+4.313	<.001	.007	3	3
UCEC	HBZP1 →	+0.026	+2.764	<.001	.001	3	3
UCEC	RNA5SP415 →	+0.298	+1.571	.001	.004	3	3
UCEC	RNA5SP412 →	+0.382	+1.426	<.001	.005	3	2
BRCA	ABHD17AP8 →	+0.102	+5.064	<.001	.004	3	2
LIHC	OR5AK1P →	+0.052	+5.647	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,524 associations by consensus.

MAGEA9B by PRPF4B expression — BRCA

Explore this box plot interactively →