PRPF4B

Across TCGA patient cohorts, PRPF4B mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF4B-associated genes across cancer lineages are eEF2, MEK1, and N-Ras. Each is linked with PRPF4B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF4B-to-partner and partner-to-PRPF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRPF4B-low versus PRPF4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF4B→partner) and Y-score (partner→PRPF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.445	+2.662	<.001	<.001	3	2
UCEC	MEK1 →	+0.354	+1.857	<.001	<.001	3	2
UCEC	N-Ras →	-0.105	-1.045	.002	.038	3	2
UCEC	PARP_cleaved →	-0.184	-2.321	.043	<.001	3	2
UCEC	PCNA →	+0.182	+1.637	.004	.001	3	2
UCEC	TIGAR →	+0.132	+1.664	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eEF2 by PRPF4B expression — UCEC

Explore this box plot interactively →