PRPF4B

Across TCGA cell cohorts, PRPF4B mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF4B-associated genes across cancer lineages are IFNA10, OR1L1, and IQCF2. Each is linked with PRPF4B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF4B-to-partner and partner-to-PRPF4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA10 grouped by PRPF4B-low versus PRPF4B-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF4B→partner) and Y-score (partner→PRPF4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IFNA10 →	+0.030	+5.087	<.001	.004	3	1
OVARY	OR1L1 →	+0.036	+5.196	<.001	.005	3	1
OVARY	IQCF2 →	+0.055	+5.196	<.001	.005	3	1
OVARY	ODF4 →	+0.042	+5.196	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
BREAST	F9 →	+0.003	+3.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

IFNA10 by PRPF4B expression — URINARY_TRACT

Explore this box plot interactively →