PRPF40B

Across TCGA pan-cancer cohorts, PRPF40B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PRPF40B data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRPF40B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRPF40B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where PRPF40B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.286	0.917	.001	47	view →
PDAC	DFS	Tertile	All	0.515	0.298	.008	29	view →
CCRCC	OS	Quartile	All	0.947	0.732	.025	10	view →
LUAD	OS	Median	II,III,IV	0.911	0.434	.010	6	view →
LSCC	DFS	Quartile	All	0.983	0.849	.025	2	view →
GBM	OS	Median	All	0.288	0.450	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PRPF40B–HNSC (DFS)

Open the HNSC breakdown →