Across TCGA patient cohorts, PRPF40A mutation is significantly associated with the RNA expression of many other genes, with 2,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF40A-associated genes across cancer lineages are MIR4515, NDUFS4, and HINT1. Each is linked with PRPF40A in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF40A-to-partner and partner-to-PRPF40A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40A→partner) and Y-score (partner→PRPF40A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4515 →	+0.321	+4.971	<.001	.005	3	3
UCEC	NDUFS4 →	+0.425	+1.747	.006	.004	3	3
UCEC	HINT1 →	+0.417	+2.265	.003	.005	3	3
HNSC	RNA5SP53 →	+0.384	+5.015	<.001	.009	3	3
COAD	PSMC1P12 →	+0.116	+3.917	.007	.007	3	3
COAD	MTCO3P38 →	+0.140	+4.271	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

Exploration

PRPF40A survival (RNA) · tumor vs normal (RNA) · all PRPF40A data types