Across TCGA patient cohorts, PRPF40A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF40A-associated genes across cancer lineages are ATM, beta-Catenin, and Caspase-7-cleavedD198. Each is linked with PRPF40A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF40A-to-partner and partner-to-PRPF40A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40A→partner) and Y-score (partner→PRPF40A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.438	-1.502	.008	.030	3	2
UCEC	beta-Catenin →	+0.433	+1.847	.020	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.740	+1.505	<.001	.034	3	2
UCEC	eEF2 →	+0.346	+3.321	.008	.009	3	1
UCEC	eIF4E →	+0.175	+1.847	.024	.008	3	1
UCEC	ERK2 →	+0.248	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

PRPF40A survival (RNA) · tumor vs normal (RNA) · all PRPF40A data types