Across TCGA cell cohorts, PRPF40A mutation is significantly associated with the RNA expression of many other genes, with 111 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPF40A-associated genes across cancer lineages are KLHL40, KSR2, and IDI2. Each is linked with PRPF40A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF40A-to-partner and partner-to-PRPF40A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40A→partner) and Y-score (partner→PRPF40A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	2
BLOOD_Leukemia	KSR2 →	+0.371	+3.061	<.001	.003	3	2
OVARY	IDI2 →	+0.021	+4.029	.001	.009	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	HSF5 →	+0.006	+4.029	<.001	.009	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

Exploration

PRPF40A survival (RNA) · tumor vs normal (RNA) · all PRPF40A data types