PRPF4

Across TCGA pan-cancer cohorts, PRPF4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PRPF4 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRPF4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PRPF4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and LSCC are the cancer types where PRPF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.882	.022	54	view →
LUAD	OS	Tertile	All	1.000	0.891	.011	15	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.708	.018	7	view →
CCRCC	OS	Median	All	0.888	1.000	.003	6	view →
GBM	OS	Median	All	0.570	0.247	.010	4	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.912	.031	2	view →
PDAC	DFS	Tertile	II,III,IV	0.896	0.621	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PRPF4–COAD (DFS)

Open the COAD breakdown →