PRPF4

Across TCGA patient cohorts, PRPF4 protein abundance is significantly associated with the RNA expression of many other genes, with 20,009 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRPF4-associated genes across cancer lineages are CXCR2, CENPF, and CENPL. Each is linked with PRPF4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PRPF4-to-partner and partner-to-PRPF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRPF4 versus CXCR2 in UCEC, with a Pearson correlation of -0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF4→partner) and Y-score (partner→PRPF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCR2 →	-0.990	-0.250	<.001	<.001	3	8
GBM	CENPF →	+1.575	+0.377	<.001	<.001	3	8
LUAD	CENPL →	+0.769	+0.217	<.001	<.001	3	8
LSCC	GTF3C4 →	+0.661	+0.300	<.001	<.001	3	8
LSCC	NUF2 →	+1.160	+0.355	<.001	<.001	3	8
HNSC	EXO1 →	+1.029	+0.242	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,009 associations by consensus.

PRPF4 vs CXCR2 — UCEC

Explore this scatter interactively →