PRPF4

Across TCGA cell cohorts, PRPF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,249 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPF4-associated GO terms across cancer lineages are Immunoglobulin heavy chain V-D-J recombination, Positive regulation of chromosome condensation, and Positive regulation of mRNA 3'-end processing. Each is linked with PRPF4 in more than 19 cancer types. Because this analysis shows association rather than direction, both PRPF4-to-partner and partner-to-PRPF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin heavy chain V-D-J recombination grouped by PRPF4-low versus PRPF4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF4→partner) and Y-score (partner→PRPF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Immunoglobulin heavy chain V-D-J recombination →	+0.187	+0.684	<.001	<.001	3	20
PANCREAS	Positive regulation of chromosome condensation →	+0.253	+1.163	<.001	<.001	3	19
STOMACH	Positive regulation of mRNA 3'-end processing →	+0.141	+1.069	<.001	<.001	3	18
OESOPHAGUS	Transcription by RNA polymerase I →	+0.114	+0.813	.002	.001	2	19
BREAST	Regulation of chromosome condensation →	+0.188	+1.049	<.001	<.001	3	18
BLOOD_Lymphoma	Protein localization to chromosome →	+0.084	+1.160	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,249 associations by consensus.

Immunoglobulin heavy chain V-D-J recombination by PRPF4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →