Across TCGA patient cohorts, PRPF39 protein abundance is significantly associated with the RNA expression of many other genes, with 13,543 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRPF39-associated genes across cancer lineages are MSH6, LAS1L, and CEP83-DT. Each is linked with PRPF39 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRPF39-to-partner and partner-to-PRPF39 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF39→partner) and Y-score (partner→PRPF39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSH6 →	+0.684	+0.157	<.001	.001	3	6
LSCC	LAS1L →	+0.481	+0.189	<.001	.001	3	6
GBM	CEP83-DT →	+0.422	+0.193	.001	<.001	3	6
HNSC	SLFNL1-AS1 →	+0.508	+0.087	<.001	.005	3	6
GBM	POLE2 →	+0.746	+0.262	<.001	<.001	3	5
LSCC	VRK1 →	+0.763	+0.181	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,543 associations by consensus.

Exploration

PRPF39 survival (RNA) · tumor vs normal (RNA) · all PRPF39 data types