Across TCGA patient cohorts, PRPF39 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF39-associated genes across cancer lineages are Src_pY527, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with PRPF39 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF39-to-partner and partner-to-PRPF39 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF39→partner) and Y-score (partner→PRPF39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.332	-1.352	.014	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.593	+1.502	.001	.025	3	2
UCEC	EGFR_pY1068 →	-0.288	-3.169	<.001	<.001	3	1
UCEC	eIF4E →	+0.190	+3.013	.004	<.001	3	1
UCEC	ERK2 →	+0.146	+1.678	.016	.021	3	1
UCEC	FASN →	+0.357	+1.925	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

PRPF39 survival (RNA) · tumor vs normal (RNA) · all PRPF39 data types