PRPF38B

Across TCGA pan-cancer cohorts, PRPF38B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PRPF38B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRPF38B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PRPF38B is over-expressed in tumor.

HNSC, COAD, and CCRCC are the cancer types where PRPF38B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPF38B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.458	<.001	11	view →
COAD	Male	III,IV	+0.413	<.001	11	view →
CCRCC	Male	All	+0.408	<.001	11	view →
LSCC	Female	II,III,IV	+0.342	<.001	8	view →
LUAD	Male	All	+0.186	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PRPF38B–HNSC

Open the HNSC breakdown →