PRPF38AP2

Across TCGA pan-cancer cohorts, PRPF38AP2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRPF38AP2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRPF38AP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRPF38AP2 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where PRPF38AP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPF38AP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.116	.028	4	view →
KIRC	Male	II,III,IV	−0.027	.005	4	view →
HNSC	All	II,III,IV	+0.023	.036	4	view →
LUSC	All	All	−0.037	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRPF38AP2–COAD

Open the COAD breakdown →